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Extramedullary myeloma in an HIV-seropositive subject. Literature review and report of an unusual case

Author(s): Feller Liviu | White Jason | Wood Neil | Bouckaert Michael | Lemmer Johan | Raubenheimer Erich

Journal: Head & Face Medicine ISSN 1746-160X
Volume: 5; Issue: 1; Start page: 4; Date: 2009;
Original page

ABSTRACT
Abstract Myeloma is characterized by monoclonal bone marrow plasmacytosis, the presence of M-protein in serum and/or in urine and osteolytic bone lesions. HIV-seropositive subjects with myeloma are younger at the time of diagnosis of the tumour and usually the myeloma has a more aggressive clinical course than it does in HIV-seronegative subjects. A case of an HIV-seropositive woman in whom myeloma was diagnosed following progressive swelling of the face, is reported. In addition to bone marrow plasmacytosis and the presence of M-protein in the serum, the patient had an extramedullary lesion affecting the oral cavity, maxilla, parotid gland and paranasal sinuses, and extending intracranially and intraorbitally.